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The Science behind AdagioVR

Where Science Becomes Experience

The Gap

The world of mental health has long been divided between illness and wellness, yet millions exist in between with unhealed stress and trauma. It is too little to be labeled a disease but enough to disrupt how they think, feel, perform, and live.

Chronic Stress

Chronic stress reshapes emotion-and-memory circuits, altering serotonin signalling and gene expression - explaining how unresolved experiences change mood and behaviour.

Joca S.R.L. et al. (2015)

Chronic Stress

Chronic stress reshapes emotion-and-memory circuits, altering serotonin signalling and gene expression - explaining how unresolved experiences change mood and behaviour.

Joca S.R.L. et al. (2015)

Chronic Stress

Chronic stress reshapes emotion-and-memory circuits, altering serotonin signalling and gene expression - explaining how unresolved experiences change mood and behaviour.

Joca S.R.L. et al. (2015)

Trauma

Trauma alters connectivity between the amygdala, hippocampus and prefrontal cortex - networks that can be reshaped through interventions that build resilience and restore regulation.

Russo S.J. et al. (2024)

Trauma

Trauma alters connectivity between the amygdala, hippocampus and prefrontal cortex - networks that can be reshaped through interventions that build resilience and restore regulation.

Russo S.J. et al. (2024)

Trauma

Trauma alters connectivity between the amygdala, hippocampus and prefrontal cortex - networks that can be reshaped through interventions that build resilience and restore regulation.

Russo S.J. et al. (2024)

Early Adversity Disrupts

Early adversity disrupts neurodevelopment and increases lifelong risk of mental and physical illness — showing why prevention must begin early.

Hughes K. et al. (2020)

Early Adversity Disrupts

Early adversity disrupts neurodevelopment and increases lifelong risk of mental and physical illness — showing why prevention must begin early.

Hughes K. et al. (2020)

Early Adversity Disrupts

Early adversity disrupts neurodevelopment and increases lifelong risk of mental and physical illness — showing why prevention must begin early.

Hughes K. et al. (2020)

Addiction

Addiction arises when stress, reward and control circuits become dysregulated - turning coping mechanisms into compulsions that sustain distress.

Koob G.F. & Volkow N.D. (2016)

Addiction

Addiction arises when stress, reward and control circuits become dysregulated - turning coping mechanisms into compulsions that sustain distress.

Koob G.F. & Volkow N.D. (2016)

Addiction

Addiction arises when stress, reward and control circuits become dysregulated - turning coping mechanisms into compulsions that sustain distress.

Koob G.F. & Volkow N.D. (2016)

Chronic stress Alters Amygdala

Chronic stress alters amygdala–prefrontal coupling, impairing emotion control and threat perception - highlighting the need for interventions that restore balance in these pathways.

Zhang W. et al. (2017)

Chronic stress Alters Amygdala

Chronic stress alters amygdala–prefrontal coupling, impairing emotion control and threat perception - highlighting the need for interventions that restore balance in these pathways.

Zhang W. et al. (2017)

Chronic stress Alters Amygdala

Chronic stress alters amygdala–prefrontal coupling, impairing emotion control and threat perception - highlighting the need for interventions that restore balance in these pathways.

Zhang W. et al. (2017)

Aspects Associated with the Amygdala

The amygdala mediates fear, attachment, and emotional learning — core processes disrupted by trauma and restored through safe multisensory engagement.

Costa P. et al. (2017)

Aspects Associated with the Amygdala

The amygdala mediates fear, attachment, and emotional learning — core processes disrupted by trauma and restored through safe multisensory engagement.

Costa P. et al. (2017)

Aspects Associated with the Amygdala

The amygdala mediates fear, attachment, and emotional learning — core processes disrupted by trauma and restored through safe multisensory engagement.

Costa P. et al. (2017)

Therapeutic frameworks

Trauma-focused therapies

Trauma-focused therapies such as EMDR and CBT enable safe reprocessing and adaptive learning without retraumatisation — principles applied in AdagioVR’s integrative design.

Bisson J.I. et al. (2017)

Trauma-focused therapies

Trauma-focused therapies such as EMDR and CBT enable safe reprocessing and adaptive learning without retraumatisation — principles applied in AdagioVR’s integrative design.

Bisson J.I. et al. (2017)

Trauma-focused therapies

Trauma-focused therapies such as EMDR and CBT enable safe reprocessing and adaptive learning without retraumatisation — principles applied in AdagioVR’s integrative design.

Bisson J.I. et al. (2017)

Cognitive Reframing

Cognitive reframing changes emotional experience by altering interpretation of events — a key element in reshaping perception and behaviour.

Beck A.T. (1996)

Cognitive Reframing

Cognitive reframing changes emotional experience by altering interpretation of events — a key element in reshaping perception and behaviour.

Beck A.T. (1996)

Cognitive Reframing

Cognitive reframing changes emotional experience by altering interpretation of events — a key element in reshaping perception and behaviour.

Beck A.T. (1996)

Emotion-regulation

Emotion-regulation research shows that attentional redirection and reappraisal enhance wellbeing and flexibility - mechanisms central to AdagioVR’s approach.

Gross J.J. (2020)

Emotion-regulation

Emotion-regulation research shows that attentional redirection and reappraisal enhance wellbeing and flexibility - mechanisms central to AdagioVR’s approach.

Gross J.J. (2020)

Emotion-regulation

Emotion-regulation research shows that attentional redirection and reappraisal enhance wellbeing and flexibility - mechanisms central to AdagioVR’s approach.

Gross J.J. (2020)

Multisensory Immersion

Meta-analysis on VR Therapies

2025 meta-analysis found VR therapies moderately improved depression in adolescents and young adults (g ≈ 0.49).

Wang H. et al. (2025)

Meta-analysis on VR Therapies

2025 meta-analysis found VR therapies moderately improved depression in adolescents and young adults (g ≈ 0.49).

Wang H. et al. (2025)

Meta-analysis on VR Therapies

2025 meta-analysis found VR therapies moderately improved depression in adolescents and young adults (g ≈ 0.49).

Wang H. et al. (2025)

Meta-analysis

Meta-analysis shows VR is effective for anxiety disorders, comparable to traditional exposure therapy outcomes.

Benito K. et al. (2023)

Meta-analysis

Meta-analysis shows VR is effective for anxiety disorders, comparable to traditional exposure therapy outcomes.

Benito K. et al. (2023)

Meta-analysis

Meta-analysis shows VR is effective for anxiety disorders, comparable to traditional exposure therapy outcomes.

Benito K. et al. (2023)

Enhanced Therapeutic Engagement

2024 systematic review finds immersive VR improves engagement and adherence in mental-health interventions across multiple conditions.

Chen S. et al. (2024)

Enhanced Therapeutic Engagement

2024 systematic review finds immersive VR improves engagement and adherence in mental-health interventions across multiple conditions.

Chen S. et al. (2024)

Enhanced Therapeutic Engagement

2024 systematic review finds immersive VR improves engagement and adherence in mental-health interventions across multiple conditions.

Chen S. et al. (2024)

Immersive Emotional Healing

VR enhances presence and safety, helping users engage emotions and process distress within controlled immersive environments.

Maples-Keller J.L. et al. (2022)

Immersive Emotional Healing

VR enhances presence and safety, helping users engage emotions and process distress within controlled immersive environments.

Maples-Keller J.L. et al. (2022)

Immersive Emotional Healing

VR enhances presence and safety, helping users engage emotions and process distress within controlled immersive environments.

Maples-Keller J.L. et al. (2022)

Adaptive Technology

Personalised Adaptive Environments

Adaptive feedback in VR creates personalised, high-control environments for self-regulation and learning.

Parsons T.D. (2015)

Personalised Adaptive Environments

Adaptive feedback in VR creates personalised, high-control environments for self-regulation and learning.

Parsons T.D. (2015)

Personalised Adaptive Environments

Adaptive feedback in VR creates personalised, high-control environments for self-regulation and learning.

Parsons T.D. (2015)

Integrated Biofeedback Regulation

Biofeedback integration within VR enables users to modulate physiological responses, enhancing emotion regulation and awareness

Benito K. et al. (2023)

Integrated Biofeedback Regulation

Biofeedback integration within VR enables users to modulate physiological responses, enhancing emotion regulation and awareness

Benito K. et al. (2023)

Integrated Biofeedback Regulation

Biofeedback integration within VR enables users to modulate physiological responses, enhancing emotion regulation and awareness

Benito K. et al. (2023)

AI-Powered Precision Care

AI-driven mental health platforms improve treatment precision and personalise user experience, expanding accessibility.

Maples-Keller J.L. et al. (2022)

AI-Powered Precision Care

AI-driven mental health platforms improve treatment precision and personalise user experience, expanding accessibility.

Maples-Keller J.L. et al. (2022)

AI-Powered Precision Care

AI-driven mental health platforms improve treatment precision and personalise user experience, expanding accessibility.

Maples-Keller J.L. et al. (2022)

Integrating Lived Experience via Blended Support

Community-Driven Support

Peer- and community-led programs enhance engagement and reduce relapse when combined with professional care.

Repper J. & Watson E. (2012)

Community-Driven Support

Peer- and community-led programs enhance engagement and reduce relapse when combined with professional care.

Repper J. & Watson E. (2012)

Community-Driven Support

Peer- and community-led programs enhance engagement and reduce relapse when combined with professional care.

Repper J. & Watson E. (2012)

Hybrid Care Solutions

Blended digital and in-person interventions improve reach and maintain strong therapeutic outcomes.

Wentzel J. et al. (2017)

Hybrid Care Solutions

Blended digital and in-person interventions improve reach and maintain strong therapeutic outcomes.

Wentzel J. et al. (2017)

Hybrid Care Solutions

Blended digital and in-person interventions improve reach and maintain strong therapeutic outcomes.

Wentzel J. et al. (2017)

Guided VR Therapy

Combining digital VR tools with human facilitation ensures psychological safety and lasting behavioural change.

Maples-Keller J.L. et al. (2022)

Guided VR Therapy

Combining digital VR tools with human facilitation ensures psychological safety and lasting behavioural change.

Maples-Keller J.L. et al. (2022)

Guided VR Therapy

Combining digital VR tools with human facilitation ensures psychological safety and lasting behavioural change.

Maples-Keller J.L. et al. (2022)

Performance & Behavior Focus

Executive Function Skills

Executive-function skills — inhibition, memory, and flexibility — are critical predictors of resilience, success, and wellbeing.

Wang H. et al. (2025)

Executive Function Skills

Executive-function skills — inhibition, memory, and flexibility — are critical predictors of resilience, success, and wellbeing.

Wang H. et al. (2025)

Executive Function Skills

Executive-function skills — inhibition, memory, and flexibility — are critical predictors of resilience, success, and wellbeing.

Wang H. et al. (2025)

Stress & Cognitive Impact

Chronic stress impairs prefrontal regulation, reducing cognitive flexibility and decision control.

McEwen B.S. & Morrison J.H. (2015)

Stress & Cognitive Impact

Chronic stress impairs prefrontal regulation, reducing cognitive flexibility and decision control.

McEwen B.S. & Morrison J.H. (2015)

Stress & Cognitive Impact

Chronic stress impairs prefrontal regulation, reducing cognitive flexibility and decision control.

McEwen B.S. & Morrison J.H. (2015)

Psychological Capital

Psychological capital — hope, efficacy, resilience, optimism — predicts performance and engagement.

Newman A. et al. (2020)

Psychological Capital

Psychological capital — hope, efficacy, resilience, optimism — predicts performance and engagement.

Newman A. et al. (2020)

Psychological Capital

Psychological capital — hope, efficacy, resilience, optimism — predicts performance and engagement.

Newman A. et al. (2020)

VR Exposure Therapy

VR exposure therapy shows large effect sizes (g ≈ 1.1) in improving PTSD and anxiety — supporting scalable, performance-enhancing applications.

McLay R. et al. (2022)

VR Exposure Therapy

VR exposure therapy shows large effect sizes (g ≈ 1.1) in improving PTSD and anxiety — supporting scalable, performance-enhancing applications.

McLay R. et al. (2022)

VR Exposure Therapy

VR exposure therapy shows large effect sizes (g ≈ 1.1) in improving PTSD and anxiety — supporting scalable, performance-enhancing applications.

McLay R. et al. (2022)

The Evidence in Harmony

Every element of AdagioVR is built on evidence - neuroscience, psychology, and lived experience working in harmony. We continue to collaborate with universities, clinicians, and communities to advance the science of relief.